By England 1958 Wolstenholme, G. E. W. ; O'Connor, Maeve, Ciba Foundation Symposium on the Biosynthesis of Terpenes and Sterols London
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Chapter 1 Chairman's beginning comments (pages 1–3): Sir Robert Robinson
Chapter 2 Biogenesis and differences of Squalene (pages 4–19): Konrad Bloch
Chapter three Discovery and Elucidation of Mevalonic Acid (pages 20–45): Karl Folkers, Clifford H. Shunk, Bruce O. Linn, Franklin M. Robinson, Paul E. Wittreich, Jesse W. Huff, James L. Gilfillan and Helen R. Skeggs
Chapter four adjustments of ldl cholesterol Biosynthesis in Liver cellphone Fractions from Rats in quite a few Experimental stipulations (pages 46–61): Nancy L. R. Bucker
Chapter five The Enzymic Synthesis of Branched?Chain Acids (pages 62–74): M. J. Coon, F. P. Kupiecki, E. E. Dekker, M. J. Schlesinger and Alice Del Campillo
Chapter 6 The Biosynthesis of ??Hydroxy???Methyl?Glutaryl Coenzyme a and its Conversion to Mevalonic Acid (pages 75–94): Harry Rudney
Chapter 7 New features of Acetate Incorporation into Isoprenoid Precursors (pages 95–118): F. Lynen, H. Eggerer, U. Henning, J. Knappe, I. Kessel and E. Ringelmann
Chapter eight The Mechanism of a Rearrangement taking place in the course of Biosynthesis of ldl cholesterol (pages 119–184): J. W. Cornforth, Rita H. Cornforth, Marjorie G. Horning, A. Pelter and G. Popjak
Chapter nine Semi?, Mono?, Sesqui?, and Triterpenes as ldl cholesterol Precursors (pages 135–147): O. Isler, R. Ruegg, G. Saucy, J. Wursch, ok. F. Gey and A. Pletscher
Chapter 10 Biosynthesis of Squalene and of ldl cholesterol from Mevalonic Acid (pages 148–172): G. Popjak
Chapter eleven Biosynthesis of Yeast Sterols and the practise of 14C?Labelled nutrition D2 (pages 173–184): E. Kodicek
Chapter 12 Bile Acids: Formation and Metabolism (pages 185–205): Sune Bergstrom
Chapter thirteen Species comparability as an relief within the learn of the method Sterols > Bile Salts (pages 206–216): G. A. D. Haslewood
Chapter 14 a few features of Acid?Catalysed Cyclizations of Terpenoid Polyenes (pages 217–230): A. Eschenmoser, Dorothee Felix, M. intestine, J. Meier and P. Stadler
Chapter 15 Biogenesis of Terpenes in Moulds and better crops (pages 231–244): D. Arigoni
Chapter sixteen The Biosynthesis of Terpenoid Compounds in Fungi (pages 245–266): A. J. Birch and Herchel Smith
Chapter 17 The Biosynthesis of Carotenoids by way of Micro?Organisms (pages 267–278): E. C. Grob
Chapter 18 A comparability of the Incorporation of Labelled CO2, Acetate and Mevalonate into Carotenoids in a few Carotenogenic platforms (pages 279–301): T. W. Goodwin
Chapter 19 Chairman's remaining comments (page 302):
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Extra info for Ciba Foundation Symposium - Biosynthesis of Terpenes and Sterols
Controls received Wesson oil. Both groups had no further food during the 24 hr. before killing. mevalonic acid and labelled squalene. It is interesting that Triton, although affording a highly potent stimulus in the intact animal, appeared to be totally ineffective when added in vitro over a wide range of concentrations. The effects of X-irradiation were studied only in fasting rats. It was necessary to deprive these animals and their controls of food because damage to the intestinal mucosa by 50 NANCY L.
By the use of a derivative of mevalonic acid which would prevent lactonization, such as 40 K A R L FOLKERS et d. the available benzhydrylamide, it was possible to obtain a phosphate (XXIV) a t position 5 without other changes in the molecule, as shown in Fig. 6. The phosphorylating agent was prepared from 85 per cent phosphoric acid and phosphoryl chloride. 6. Phosphate of mevalonic acid. a solution of monochlorophosphoric acid in 100 per cent phosphoric acid. Reaction a t room temperature gave a good yield of the 5-phosphate of mevalonic acid benzhydrylamide (XXIII).
F)-Mevaldic acid was essentially inactive for the growth of L. acidophilus for its activity was no more than about 11200 that of ( &)-mevalonicacid. Table VII contains data on the inhibition of the incorporation of [l-14C]acetate into cholesterol by mevaldic acid (MALD). C) 2,168 3,864 8,093 - - 1,787 3,4Q4 7,355 - (A) sDec. /100 pg. /100 pg. by flow gas counter . I I mevalonic acid when a rat liver homogenate system is used. The corresponding dimethyl acetal of mevaldic acid was inactive for the growth of L.