Ciba Foundation Symposium 122 - Calcium and the Cell

This number of displays from the Ciba origin Symposium of 1985 offers with the primary position of calcium in intracellular strategies. Discusses regulate of intracellular calcium in addition to regulate by means of intracellular calcium, protecting such themes as muscle contraction, metabolic strategies, hormone and transmitter secretion, membrane shipping and permeability, mobile structure and progress, and the prospective contribution of calcium gradients to early embryonic improvement. contains conscientiously edited and huge (almost part the e-book) discussions of bankruptcy themes among lively employees within the box on the finish of every bankruptcy.


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3). The presence of charge movement in the absence of release could be due to charge movement unrelated to calcium release or could indicate the existence of charge movements that are part of the voltage-sensing mechanism for calcium release but are preliminary to the final step that actually controls the opening of the channel. The latter interpretation is supported by two observations on the effects of subthreshold prepulses. If a given test pulse was immediately preceded by a subthreshold prepulse, (1) the test pulse duration required to produce detectable contraction was decreased (Horowicz & Schneider 1981b) and (2) the latency before the start of the test pulse calcium transient was decreased without other changes, providing the test pulse was relatively long (Schneider et a1 1981).

Equality of ON and OFF charge movements is observed in frog muscle for pulses of tens or hundreds of ms. However, for pulses lasting tens of seconds the charge movement disappears and reappears only after seconds or tens of seconds of repolarization (Chandler et a1 1976). The fact that the time course of disappearance of charge movement during prolonged depolarization (Chandler et al 1976) was similar to the time course of development of the mechanically refractory state (Hodgkin & Horowicz 1960) was an early indication that muscle charge movement is involved in the control of calcium release.

Putnev: Dr Schneider, you suggest that calcium-induced calcium release is inconsistent with the graded calcium release that you measure. It is my impression that Fabiato (1983) has shown that the calcium-induced calcium release was not just calcium concentration-dependent, but dependent on the rate of application of calcium to the SR. which would give graded release. Also, calcium may not enter across the T-tubule membrane (and that is why there is no current), but it might be released from the inner aspect of the T-tubule membrane, and that might be a mechanism for coupling in skeletal muscle.

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