Cholera Toxins by Dr. Keya Chaudhuri, Prof. S. N. Chatterjee (eds.)

By Dr. Keya Chaudhuri, Prof. S. N. Chatterjee (eds.)

Vibrio cholerae, the causative organism of the sickness Cholera, colonizes the small gut and produces a number of assorted pollutants between which the enterotoxin, or extra widely recognized as cholera toxin (CT), occurs to be the foremost virulence determinant that's answerable for the diarrheal syndrome. This e-book offers for the 1st time finished and updated information regarding the entire pollutants of Vibrio cholerae, their actual and chemical constructions, their biosynthesis and its genetic rules, their body structure, the molecular biology in their interactions with the host in addition to their function within the improvement of a suitable and potent cholera vaccine. It additionally deals proper and worthy historical past info at the easy biology of the Vibrio cholerae phone and cholera bacteriophages.

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Cholerae did not receive any significant attention until the mid1980s (Guidolin and Manning 1987). The few exceptions included the discovery of the conjugal system in V. cholerae by Bhaskaran (1958). It was shown that the conjugation in V. cholerae was mediated by the P factor, which, unlike the F factor of E. coli, could not integrate into the chromosome, and hence could not induce Hfr donors (Datta et al. 1973). Few plasmids were reported to be present in V. cholerae. The Bhaskaran strain 162 was shown to contain two plasmids besides P (Datta et al.

Of ORF sizea proteinsc operons proteins codingb 94 4 4 92 112 14 100 12 No. 8 Genetics of V. cholerae: An Outline of Some Relevant Areas 31 was possibly captured by an ancestral Vibrio species (Heidelberg et al. 2000). The origin of chromosome II, however, continues to be the subject of further investigations. Recently, the origins of replication of the two chromosomes have been defined and novel replicon-specific requirements for each chromosome as well as factors required for the replication of both chromosomes are found (Egan and Waldor 2003).

1974). The single polar flagellum lies attached to a structure in the bacterial protoplasm called the basal granule, which is about 650 Å in size (Fig. 1). The bacterial protoplasm is bounded by a membrane called the plasma membrane. The plasma membrane exhibits a trilamellar structure and has an overall thickness of about 75 Å. On the outer side of the plasma membrane there is the periplasmic space of thickness 50–100 Å. The periplasmic space is again bounded by another layer of membranous structure, the cell wall, which consists of a thin layer of peptidoglycan covered by another trilamellar structure at the outermost periphery of the cell.

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