This quantity covers tracking of the biotechnological method with refined analytical thoughts, use of the ensuing facts via mathematical versions, and computer-aided keep watch over for development of the productiveness of biotechnological processes.
The e-book comprises 4 major elements: tools for research and biosensoring, measuring options, approach versions and their automation and keep watch over. using various telephone forms, recombinant microorganisms, and reactor stipulations are offered and all current concepts of tracking and optimizing mobilephone development and product formation are mentioned with reference to enhanced productivity.
issues incorporated are: tools and tools/ Biosensors/ Characterization of Bioreactors/ choice of phone focus/ telephone types/ Stirred Tank types/ Tower Reactor types/ strategy types/ keep watch over of Bioreactor structures/ Automation/ regulate of Downstream Processing
Chapter 1 universal tools for technique research and keep an eye on (pages 4–25): Karl Schugerl
Chapter 2 equipment and tools in Fermentation gasoline research (pages 27–74): Elmar Heinzle and Irving J. Dunn
Chapter three Biosensors (pages 75–103): Bo Mattiasson
Chapter four Characterization of Bioreactors (pages 107–148): Andreas Lubbert
Chapter five On?Line research of Broth (pages 149–178): Karl Schugerl
Chapter 6 selection of mobile focus and Characterization of Cells (pages 179–223): Kenneth F. Reardon and Thomas H. Scheper
Chapter 7 Bioreactor country Estimation (pages 225–249): Gregory Stephanopoulos and Seujeung Park
Chapter eight Optimization of Sampling (pages 251–264): Axel Munack
Chapter nine telephone versions (pages 267–298): Karl?Heinz Bellgardt
Chapter 10 Stirred Tank types (pages 299–348): Matthias Reuss and Rakesh Bajpai
Chapter eleven Tower Reactor versions (pages 349–382): Jose C. Merchuk
Chapter 12 method versions: Optimization of Yeast construction — A Case examine (pages 383–406): Karl?Heinz Bellgardt and Jingqi Yuan
Chapter thirteen cardio Wastewater technique types (pages 407–439): Graham F. Andrews
Chapter 14 Anaerobic Waste Water method types (pages 441–484): Dirk Schurbuscher and Christian Wandrey
Chapter 15 Bioprocess Kinetics and Modelling of Recombinant Fermentation (pages 485–505): Dewey D. Y. Ryu, Jeong?Yoon Kim and sunlight Bok Lee
Chapter sixteen keep an eye on of Bioreactor structures (pages 509–560): Henry C. Lim and Kyu?Sung Lee
Chapter 17 Automation in Biotechnology (pages 561–602): Andreas Lubbert
Chapter 18 Modelling, layout, and keep watch over of Downstream Processing (pages 603–623): Suteaki Shioya and Ken?Ichi Suga
Chapter 19 specialist structures for Biotechnology (pages 625–636): Aarne Halme and Nazmul Karim
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Extra resources for Biotechnology: Measuring, Modelling, and Control, Volume 4, Second Edition
1990). This examH20 ple is later also used to analyze error propagaThe elemental balances are: tion (Sect. 4). Stoichiometry (69) (73) Application of Gas Analysis Results to Elemental Balancing Methods 43 The above relations contain 6 unknowns and 3 equations; thus, measuring any 3 unknowns will determine the system. This means that if the fluxes of ammonia, oxygen, and carbon dioxide are measured, the calculation of the fluxes of substrate, cell biomass, and product is straightforward. Fig. 7.
0012 , would partially explain the deviations observed in this experiment. The influence of errors in gas analysis on the estimation of gas reaction rates and fluxes of biomass, substrates, and product is discussed in more detail in the following Sect. 4. 4 Error Analysis for Gas Balancing off-line 0 0 0' = CNH4+,0 + In most cases the choice of a method for gas analysis and equipment depends on the required accuracy and reliability. These are usually difficult to define because of the complexity of error propagation.
08314bar L mol-' K - I ) respiratory quotient (-) relative statistical error (-) time (s) temperature (K, "C) velocity (m s-') volume (m3, L) biomass concentration (g L - I ) gas phase molar fraction ( - ) thickness (m) time constant (s) molar flux (=specific reaction rate) (mol kg-ls-') Subscripts and Superscripts E electrode G gas phase i index for component inert inert gas L liquid phase re1 relative X biomass 0 input into the reactor 1 output from the reactor * refers to gas-liquid equilibrium ' relative value ( - ) 29 30 2 Methods and Instruments in Fermentation Gas Analysis 1 Introduction gen and CO, production can be measured simultaneously by first measuring pressure change and subsequently absorbing CO, in an It is evident from Chapter 1 of this volume alkaline solution, then making a final pressure of “Biotechnology” that on-line fermentation measurement.