By R. Weindruch (auth.), Lawrence Fishbein PhD (eds.)
How does nutritional limit have an effect on the physiological and biochemical kingdom of laboratory animals? How will the current conclusions impact additional study? What are the consequences for human wellbeing and fitness and safeguard evaluate? those are the most questions requested during this ebook by way of major overseas researchers. After a primary examine feeding regimens and diets of laboratory animals, the publication elaborates on quite a few age-associated toxicological and pathological endpoints together with tumor improvement. the next sections element the underlying mechanisms that could set off the extensive spectrum of physiological and biochemical alterations. This precis of present multidisciplinary learn will increase realizing of the sensible functions and implications of nutritional restriction.
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Extra resources for Biological Effects of Dietary Restriction
Furthermore, caloric restriction has been shown to delay the onset of puberty, decrease serum FSH and progesterone levels, and increase serum 17B-estradiollevels in rats (Holehan and Merry 1985). While hormonal imbalances. may enhance promotion and contribute to the incidence of spontaneous tumor expression, modulation of chemically induced cancers through caloric restriction must certainly involve the metabolic capabilities of the animal and, therefore, the initiation process. As was referenced earlier, caloric restriction effectively reduced the incidence ofmethyl-azo-methanol-induced (indirect-acting) colon tumors, but had no effect on methylnitrosourea-induced (direct-acting) colon tumors (Pollard and Luckert 1985).
Concentrations of detectable levels of contaminants in the NIH-31 open formula autoclavable diet (Knapka 1983) from two sources and users (Oller et al. 3. 2). 4, (Oller et al. 1989; Ralston Purina, unpublished data). 3). 5. Concentrations of the selected contaminants were lower and close to the minimum detectable levels. 3). N. 4. Concentrations of selected contaminants in two types of closed formula nonpurified diets. 18 NA, not done or not available. aManufactured by Ralston Purina, St. Louis.
Caloric restriction generally decreases the initiation and promotion of 3. Significance of Dietary Contaminants in Diet Restriction Studies 23 tumors induced by chemicals requiring metabolic activation (Tannenbaum 1940; Pollard and Luckert 1985; Pariza 1986 and the references listed therein) such as methylazoxymethanol and dimethy1benzanthracene (DMBA). In summary, common dietary contaminant concentration in controlled diets may not have different biological effects in diet restricted animals than in ad libitum fed animals.