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Biennial Review of Infertility: Volume 3 by Peter N. Schlegel M.D. (auth.), Peter N. Schlegel, Bart C.

By Peter N. Schlegel M.D. (auth.), Peter N. Schlegel, Bart C. Fauser, Douglas T. Carrell, Catherine Racowsky (eds.)

In this 3rd quantity, the Biennial overview of Infertility brings jointly the main up to date examine and scientific details on female and male infertility, rising assisted reproductive ideas, and debatable concerns in reproductive medication. a powerful panel of members offers state of the art details in a transparent and well-balanced demeanour. This quantity comprises scorching subject matters in reproductive drugs together with age and its influence on fertility, way of life elements and reproductive health and wellbeing, fertility protection for melanoma sufferers, reproductive tourism and a dialogue of medical examine layout. The multiplied part on controversies allows point/counterpoint dialogue among specialists with differing critiques on themes like safeguard of the ICSI method and the function of IUI in smooth reproductive medication. Created to supply an ongoing appraisal of present wisdom, the Biennial overview of Infertility stimulates conversation among all these operating to aid unravel their infertility.

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Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am J Hum Genet. 2012;90(2):175–200. 70. MacDonald ME, Ambrose CM, Duyao MP, et al. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell. 1993;72(6):971–83. 71. Duyao M, Ambrose C, Myers R, et al. Trinucleotide repeat length instability and age of onset in Huntington’s disease. Nat Genet. 1993;4(4):387–92. 72. Goldberg YP, Kremer B, Andrew SE, et al.

However, unlike telomere attrition that occurs in the majority of other cell types, the telomeres length in sperm actually increases with age. Genetic changes to sperm are discussed in the following section. 1 DNA Damage Numerous studies have reported an age-related increase in sperm DNA damage [12–16]. The increase in DNA fragmentation index (DFI) is marked, with a nearly fourfold increase in men age 60–80 compared with men age 20–29 reported in one study [14]. In a large study of 1,125 men from infertile couples, DFI more than doubled in men over the age of 45 compared with men aged 30 and younger [16].

2001;9(7): 533–8. 24. Griffin DK, Abruzzo MA, Millie EA, et al. Nondisjunction in human sperm: evidence for an effect of increasing paternal age. Hum Mol Genet. 1995;4(12): 2227–32. 25. Lowe X, Eskenazi B, Nelson DO, et al. Frequency of XY sperm increases with age in fathers of boys with Klinefelter syndrome. Am J Hum Genet. 2001; 69(5):1046–54. 26. Conrad DF, Keebler JE, DePristo MA, et al. Variation in genome-wide mutation rates within and between human families. Nat Genet. 2011;43(7):712–4. 27.

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