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Axon Growth and Guidance by Céline Bouquet, Fatiha Nothias (auth.), Dominique Bagnard

By Céline Bouquet, Fatiha Nothias (auth.), Dominique Bagnard Ph.D. (eds.)

The complexarchitectureofneuronal networks togetherwith the intense linked services make the anxious procedure a desirable organic constitution. The huge paintings played to discover this mobile equipment is these days successfulbecause the mysteryofnervous process developmentisbeing unravelled. As defined of their impressive evaluate released 10 years in the past in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular period of axon guidance-summarized the meeting of worried method connections as a sophisticated video game of appeal and repulsion of neuronal development cones. The mobile ballet making sure the formation of billions of synapses, which finally supplies upward push to the top cognitive capabilities, is essentially orchestrated by means of a step by step mechanism of development pushed by way of a number of molecular cues. whereas our common inspiration of axon counsel continues to be exact, a profound evolution ofour wisdom ofthe molecular identityofthe advice cues including their interactions and signalling pathways happened over the last ten years. This ebook proposes an exhaustive and up-to-date view ofthe present wisdom ofthe molecular and mobile mechanisms making sure axon progress and tips. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the beneficial properties ofa progress cone and the mechanisms controlling its progress. From there, one enters a wonderful trip with a development cone, a Tom Thumb tale full of molecular encounters and intricate interactions resulting in one ofthe most fabulous developmental achievements: the fearful process wiring.

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Ca2+-dependent regulation of rho GTPases rriggers turning of nerve growth cones. J Neurosci 2005; 25:2338-2347. 77. Leung-Hagesteijn C, Spence AM, Stern BD et al. UNC-5, a transmembrane protein with immunoglobulin and rhrombospondin type 1 domains, guides cell and pioneer axon migrations in C. e1egans. Cell 1992; 71:289-299. 78. Ackerman SL, Kozak LP, Przyborski SA et al. The mouse rosrral cerebellar malformation gene encodes an UNC-5-1ike protein. Nature 1997; 386:838-842. 79. Leonardo ED, Hinck L, Masu M et aI.

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Texture of the Nervous System of Man and the Vertebrates. Vienna/New York: Springer, 1999. 2. Tessier-Lavigne M, Goodman CS. The molecular biology of axon guidance. Science 1996; 274:1123-1133. 3. Tessier-Lavigne M, Placzek M, Lumsden AG er aI. Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 1988; 336:775-778. 4. Placzek M, Tessier-Lavigne M, ]essell T et aI. Orientation of commissural axons in vitro in response to a floor plate-derived chemoamactant. Development 1990; 110:19-30.

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