By Céline Bouquet, Fatiha Nothias (auth.), Dominique Bagnard Ph.D. (eds.)
The complexarchitectureofneuronal networks togetherwith the intense linked features make the fearful approach a desirable organic constitution. The massive paintings played to discover this mobile equipment is these days successfulbecause the mysteryofnervous procedure developmentisbeing unravelled. As defined of their notable evaluate released 10 years in the past in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular period of axon guidance-summarized the meeting of apprehensive method connections as a sophisticated video game of charm and repulsion of neuronal development cones. The mobile ballet making sure the formation of billions of synapses, which finally provides upward push to the top cognitive capabilities, is essentially orchestrated by way of a step by step mechanism of development pushed by means of a number of molecular cues. whereas our basic proposal of axon counsel is still exact, a profound evolution ofour wisdom ofthe molecular identityofthe suggestions cues including their interactions and signalling pathways happened during the last ten years. This ebook proposes an exhaustive and up-to-date view ofthe present wisdom ofthe molecular and mobile mechanisms making sure axon development and tips. An introductory chapterby C. Bouquetand F.Nothias will remind the readers ofall the gains ofa development cone and the mechanisms controlling its development. From there, one enters a superb trip with a development cone, a Tom Thumb tale choked with molecular encounters and complicated interactions resulting in one ofthe most fabulous developmental achievements: the frightened approach wiring.
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Extra info for Axon Growth and Guidance
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma NIE-115 cells. J Cell Bioi 1998; 141:1625-36. 97. Amano M, Chihara K, Nakamura N et al. Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 1998; 3:177-88. 98. Pruyne 0, Evangelista M, Yang C et al. Role of formins in actin assembly: Nucleation and barbed-end association. Science 2002; 297:612-5. 99. Palazzo AF, Cook TA, Alberts AS et al.
Other Potential Netrin Receptors Other receptors , in addition to DCC and UNC5 proteins, have been suggested for netrins 1-3. 99 However, subsequent studies provided evidence that AlB is neither expressed by these neurons nor required for commissural axon guidance in response to netrin-1. 67 The a6~4 and a3~1 integrins bind netrin-I and these interactions have been implicated in the development of the pancreas. 1OO Given the homology of the N-terminus of netrin-I to laminins, it might be predicted that netrins would bind integrins through N-terminal domains; but surpris ingly a6~3 and a3~ 1 integr ins interact with a highly charged sequence of basic amino acids at the C-terminus of netrin-I that is not homologous to laminins.
Tanikawa C, Matsuda K, Fukuda S et al. p53RDLl regulares p53-dependent apoptosis. Nat Cell Bioi 2003; 5:216-223. 95. Ming GL, Song H], Berninger B et al. cAMP-dependent growth cone guidance by netrin-I. Neuron 1997; 19:1225-1235. 96. Bouchard ]F, Moore SW, Tritsch NX et al. Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. I Neurosci 2004; 24:3040-3050. 97. Moore SW, Kennedy TE. Protein kinase A regulates the sensitivity of spinal commissural axon turning to netrin-I but does not switch between chemoattraction and chemorepulsion, ] Neurosci 2006; 26:2419-2423.