By Gianni Marone
This publication updates the former insurance of the mechanisms and mediators of bronchial asthma and its therapy. It offers articles via the key names within the box.
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Additional resources for Asthma and Allergic Diseases: physiology, immunopharmacology, and treatment
The fl chain locus is on chromosome 7, and the e chain locus is on chromosome 14. The 6 chain genes are found within the c~ chain locus. Enormous potential for T C R variety follows from the presence of many variable (V) and junctional (J) segments within the T C R loci. However, use of the TCR-Vc~ and -Vfl segments by lymphocytes is not random, and may be under genetic control (35-38). 8 WILLIAM O. C. M. COOKSON from the TCR-a/6 and TCR-fl regions (39). Two independent sets of families, one British and one Australian, were investigated.
23:1277-1283, 1993. 22 WILLIAM O. C. M. C O O K S O N 43. Heinzel, F. , Sadick, M. , Mutha, S. S. and Locksley, R. M. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015, 1991. 44. Mohapatra, S. , Ansari, A. , Maggi, E. and Romagnani, S. Molecular basis of cross-reactivity among allergen-specific human T cells. T-cell receptor Ve gene usage and epitope structure.
Clin. Exp. Allergy 27:574-577, 1997. Loveridge, J. , Rosenberg, W. M. , Kirkwood, T. B. L. and Bell, J. I. The genetic contribution to human T-cell receptor repertoire. Immunology 74:246-250, 1991. Moss, P. A. , Rosenberg, W. M. , Zintzaras, E. and Bell, J. I. Characterization of the human T cell receptor a-chain repertoire and demonstration of a genetic influence on V~ usage. Eur. J. Immunol. 23:1153-1159, 1993. , Posnett, D. , Janson, C. , Gregersen, P. K. and Silver, J. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type.