Asthma and Allergic Diseases: physiology, by Gianni Marone

By Gianni Marone

This publication updates the former insurance of the mechanisms and mediators of bronchial asthma and its therapy. It offers articles via the key names within the box.

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The fl chain locus is on chromosome 7, and the e chain locus is on chromosome 14. The 6 chain genes are found within the c~ chain locus. Enormous potential for T C R variety follows from the presence of many variable (V) and junctional (J) segments within the T C R loci. However, use of the TCR-Vc~ and -Vfl segments by lymphocytes is not random, and may be under genetic control (35-38). 8 WILLIAM O. C. M. COOKSON from the TCR-a/6 and TCR-fl regions (39). Two independent sets of families, one British and one Australian, were investigated.

23:1277-1283, 1993. 22 WILLIAM O. C. M. C O O K S O N 43. Heinzel, F. , Sadick, M. , Mutha, S. S. and Locksley, R. M. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4 + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl. Acad. Sci. USA 88:7011-7015, 1991. 44. Mohapatra, S. , Ansari, A. , Maggi, E. and Romagnani, S. Molecular basis of cross-reactivity among allergen-specific human T cells. T-cell receptor Ve gene usage and epitope structure.

Clin. Exp. Allergy 27:574-577, 1997. Loveridge, J. , Rosenberg, W. M. , Kirkwood, T. B. L. and Bell, J. I. The genetic contribution to human T-cell receptor repertoire. Immunology 74:246-250, 1991. Moss, P. A. , Rosenberg, W. M. , Zintzaras, E. and Bell, J. I. Characterization of the human T cell receptor a-chain repertoire and demonstration of a genetic influence on V~ usage. Eur. J. Immunol. 23:1153-1159, 1993. , Posnett, D. , Janson, C. , Gregersen, P. K. and Silver, J. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type.

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