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Activation of Hormone and Growth Factor Receptors: Molecular by M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis,

By M. N. Alexis, C. E. Sekeris (auth.), Dr. Michael N. Alexis, Prof. Constantin E. Sekeris (eds.)

This quantity includes the papers awarded within the NATO complicated learn Workshop "Activation of Hormone and progress issue Receptors: Molecular Mechanisms and effects" held in Nafplion, Greece on September 25-30, 1988. the target of NATO ARW is to evaluate the nation of-the-art in a given medical quarter and to formulate ideas for destiny examine in rising components of technology through selling foreign clinical contacts. within the Nafplion assembly this target was once reached through a global crew of audio system, senior Greek scientists and graduates fascinated about appropriate study parts. The Workshop used to be made attainable by means of the beneficiant aid of the clinical Council of NATO. We thank Drs. G. Sinclair and L.V. daCunha, administrators of the NATO ARW's and ASI's (Advanced research Institutes) respectively, for his or her wholehearted aid and suggestion. The overseas Union of Biochemistry presented extra shuttle offers resulting in elevated overseas participation. additionally, the Secretariat of technological know-how and expertise, the Ministry of tradition and Sciences and the nationwide Hellenic study starting place contributed financially and by means of aiding body of workers. We basically thank these types of corporations for his or her help. Our heartful thank you also are prolonged to the Mayor of the Municipality of Nafplion, Mr.

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The primary structure of cholera toxin subunit B. As stated before, when subunit B was separated and renatured, it formed a pentamer with Mr =55,OOO (Table 1). The molecular weight was similar to that of choleragenoid (56,000 Mr) previously reported (15). The renatured B subunit was found to form precipitate with anti-choleragen 35 antibody in a double-diffusion plate, as well as with ganglioside GM (Fig. 5). These data indicate that B subunit (pentamer of B) is identical to choleragenoid, and that it is responsible for the binding of cholera toxin to the cell surfaces.

Amino acid analyses of the subunits indicated that each contained 2 cysteine residues per mole. On complete reduction and Scarboxymethylation. subunit A was dissociated further into two components that could be separated on Sephadex G-75 in 5% formic acid (Fig. Ic). 500 respectively for the polypeptide Al and A2. Each was found to contain a single cysteine residue per mole. The experiments clearly indicated that subunit A was composed of two peptides linked to each other by a single disulfide bond.

Sci. 80: 945-949. R (1985) Nature 318: 183-186. R (1985) J. Bioi. Chem. 260: 9470-9478. P. (1984) J. BioI. Chem. 259: 5277-5286. , Roth, J. (1983) Biochem. Biophys. Res. Commun. 116: 1129-1135. H. Moo1enaar The Netherlands Cancer Institute P1esman1aan 121 1066 ex Amsterdam The Netherlands Introduction The proliferation of cells in vivo and in culture is tightly regulated by polypeptide growth factors. Like all polypeptide hormones, growth factors initiate their action by binding to specific, high affinity receptor molecules on the cell surface.

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